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Li, H., Ren, K., Jiang, T., & Zhao, G
It has been shown that PL can selectively induce the death of head and neck cancer cells and increase cisplatin antitumor activity, involving the JNK and PARP death pathways [196]
is supported by the NIH (NS112727 and AI144004)
Notably, supplementation with 5-methyl-THF reversed longevity of long-lived mutants, of reduced insulin signaling (rIIS), inherently caloric restricted, and mitochondrial mutants, while folic acid supplementation did not alter lifespan of wt nematodes [63]
