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Briefly, after being ingested by triatomines with a blood meal, parasite goes through an active binary division as an epimastigote in the insect gut

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A phase I safety study in healthy adults confirmed that subcutaneous MOTS-c injections at doses up to 10 mg produced no serious adverse events, with a pharmacokinetic profile supporting once-daily or every-other-day dosing [3]

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doi:10.1371/journal.pone.0197583 Cohen AT, Bauersachs R