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Histological examination shows a tumor with a multinodular growth pattern composed of nests and/or cords of large-sized epithelioid cells with abundant eosinophilic to amphophilic cytoplasm and large rounded nuclei with vesicular chromatin and prominent nucleoli (Figure 24)

This process is called gluconeogenesis

A family history of melanoma, the presence of multiple or atypical naevi and immunosuppression (for example following organ transplantation or long-term immunosuppressive therapy) also increase risk

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doi:10.1016/j.biopha.2022.113775 Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY, Huang Y