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Hazzard's geriatric medicine and gerontology (Seventh ed.)

doi: 10.3389/fimmu.2017.00521 50 RomaldiniJHBiancalanaMMFigueiredoDIFarahCSMathiasPC
Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis

The half-life is approximately 6 days

Thus, our findings provide strong evidence that SIRT2 directly interacts with GCLC
