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The elucidation of signaling pathways involved in the regulation of the tight junction would allow the identification of novel barrier-restoring agents, which is imperative for deciphering novel and potent approaches for disease treatment

(2024a) revealed that residents adapted to high altitude exhibit significantly reduced intestinal uric acid levels, correlating with persistently high abundances of the genera Collinsella, Blautia A , and Enterocloster key bacterial taxa involved in uric acid degradation