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In addition to targeting VEGF/VEGFR signaling, rhamnetin also interferes with the function of HIF-1, a transcription factor that becomes stabilized in hypoxic tumor environments and drives the expression of VEGF and other pro-angiogenic genes

References 1.Peitzsch C., Gorodetska I., Klusa D., Shi Q., Alves T.C., Pantel K., Dubrovska A

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Disruptions in gut microbiota composition may exacerbate inflammation through the vagal nerve and the weakened BBB, establishing a feedback loop which accelerates disease progression 46

Beyond impairments in cavernosal relaxation, ROS accumulation and oxidative stress linked to AGE formation promote reductions in antioxidant responses, lipid peroxidation, DNA damage, and oxidative protein modifications [37,38]