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The stratum corneum, the outer layer of skin, is a lipophilic barrier designed to keep hydrophilic molecules out

Night pain is typically the most problematicbut multimodal pain programs, heat, and sleeping elevated can improve this difficulty
A study found that higher CXCL9 levels decreased T cell expression, which accelerated tumor growth in transgenic mice

doi: 10.1128/JCM.43.7.3380-3389.2005
