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In the present study, we investigated a single affected individual (III-7) with MTHFR deficiency demonstrating severe features such as microcephaly, delayed growth, ophthalmic issues, non-obstructive hydrocephalus, elevated blood homocysteine level, and elevated plasma methionine levels

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This makes it easier to model dose-response relationships, timing controls, and environmental condition testing

This mechanism plays a crucial role in tissue regeneration and wound healing

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