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The children were born between January 2005 and April 2010 in the Tuscany or Umbria Regions of Italy where an expanded neonatal screening was performed on dried blood spots (DBS)

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Miscellaneous: The categories miscellaneous include amino-acids such as tryptophan and L-tryptophan, 5-hydroxytryptophan, phenylalanine , and theanine , as well as man-made chemicals such as vinpocetine and sulbutiamine and other various molecules such as beta-asarone, PRE-084 , and RO-4491533