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J Am Coll Cardiol 2000

J Mol Cell Cardiol 2011;51:600-6

10.1002/iub.1616 40 DringenR

While NAFL is typically accompanied by a lower risk of liver-related mortality, it can progress to non-alcoholic steatohepatitis (NASH) ( Although there has been a lot of effort in developing non-invasive tools for NAFLD diagnosis, the diagnosis of NAFLD is mainly based on liver biopsy ( Exosomes are nanosized extracellular vesicles that have significant roles in the pathogenesis of different diseases ( 2 Exosomes Exosomes are bi-lipid membrane extracellular vesicles sized from 50 to 140 nm ( Exosome biogenesis involves complex intracellular pathways with distinct mechanisms for different EV subtypes ( Recognition of Ubiquitinated Cargo is the first step in exosome biogenesis ( Recent findings suggest the existence of an alternative pathway for sorting exosomal cargo into MVBs in an ESCRT-independent manner ( in vivo

Antioxidant supplementation may provide therapeutic benefits by addressing oxidative stress and potentially delaying or reducing the severity of premature graying