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Further, icariside II significantly increases the phosphorylation levels of ERK1/2, Akt and JNK1/2 suggesting that the Nrf2/ARE pathway plays an important role in the regulation of icariside-mediated antioxidant effects in HepG2 cells [45]

Researchers observed that within 96 hours, the group treated with sea fennel extract had significantly lower transepidermal water loss than the placebo group, indicating faster recovery of epidermal structure and function

Critically, these effects were absent in 3-AR knockout mice, indicating that an intact 3-AR pathway is required for the lipolytic activity

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D., Patel, M., & Chung, M