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We have previously shown that Tubastatin-A (TubA), an HDAC6 inhibitor, provides protection from hepatic IRI and APAP []

EGT deficiency only decreased resistance to high H2O2 levels which suggests functionality as an auxiliary antioxidant, required for growth at elevated oxidative stress conditions

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Our results provide new insights into the structure of -GCS-GS and suggest -GCS-GS evolved from a monomeric -GCS that became C-terminally fused to a multimeric ATP-grasp protein.