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Description
GPCR researchers are interested in looking at the ways signaling molecules bind and interact with GPCRs, the kinetics of these interactions (binding kinetics), working out which G protein subunit is coupled to a specific GPCR, looking at how some ligands selectively activate some signaling pathways while blocking others (GPCR-biased agonism), or revealing the many downstream effects that ultimately lead to a functional response within a cell
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Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes
