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This peroxidase activity is mediated by a reduced cysteine residue (also referred to as peroxidatic Cys) that donates its electron to neutralize peroxide and then recycle back into its native form with the help of reductants like thioredoxin (Prdx1-5) and glutathione (Prdx6)

This recent original paper presents data on a potential new treatment for WD, which may address some unmet needs associated with currently available therapies

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The peptide appears to act by activating proteasomal degradation pathways and reducing mitochondrial oxidative stress

Indeed, LAT1/SLC7A5 expression has been reported to be increased in several cancer types [13,14]