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doi: 10.1016/j.bcp.2024.116400 111 EscribanoP.GmezA.ReigadasE.MuozP.GuineaJ
It is a cytotoxic -oxoaldehyde compound that is highly reactive and produced through different enzymatic and non-enzymatic reactions
10.1016/j.bone.2005.03.018
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It is well recognized that cartilage matrix degradation is stimulated by inflammatory factors, such as tumor necrosis factor-alpha (TNF-) and interleukins (IL-1 and IL-7), and the production of matrix metalloproteinase-13 (MMP-13), which can degrade the major components of the ECM [26, 27]
