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The ubiquity of the S-layer and its function as a physical barrier at the host-pathogen interface renders the S-layer a very important target in the search for antimicrobials effective against medically important bacteria, such as Clostridioides difficile

Cell 33 , 549561 (2015)

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Conversely, ultrasonography can result in compression effects due to the use of the ultrasound probe, potentially leading to misinterpretation of the thicknesses of the skin and subcutaneous layers

Importantly, undeniably, age is the first and foremost comorbidity, and should also be evaluated in the accurate diagnosis of CRP
