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For skin-focused goals, topical application is the preferred method

Results from a randomized, controlled, double-blinded trial in a Danish population

doi: 10.1016/S0016-5085(76)80010-8

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Similar findings were reported in a 2024 meta-analysis of probiotics and synbiotics in critical illness, that found decreased risk of ventilator associated pneumonia and length of mechanical ventilation without a change in hospital mortality [317]