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However, these are often mild and go away in a few hours to days

Fang F, et al
doi:10.1002/jor.23875 12

One key contributor to this metabolic inefficiency is the age-related decline in nicotinamide adenine dinucleotide (Lananna et al.) levels in the mitochondrial salvage pathway, which disrupts the Krebs cycle, reduces ATP production, and impairs DNA repaircascading into neuronal stress and degeneration (Baszczyk, 2020)
Numerical data was expressed as mean and standard deviation or median and range as appropriate