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GCLC succinylation leads to a decreased enzymatic activity To precisely locate the K sites undergoing succinylation modification, we individually mutated all forty lysine sites of GCLC to arginine (R) (mimicking the desuccinylated state)

There is a close bidirectional regulatory relationship between ERS and oxidative stress

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3 Pathological Mechanism and Risk Factors of Ferroptosis In fact, among the many pathological mechanisms of delayed wound healing in diabetic ulcers, the idea that hyperglycemia-induced free radicals and oxidative stress lead to cell death and exacerbate the delayed healing of diabetic ulcers has received extensive attention in recent years

Hybrid superparamagnetic iron oxide nanoparticle-branched polyethylenimine magnetoplexes for gene transfection of vascular endothelial cells