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hence, it has a vital role in antioxidant defense

Intriguingly, antioxidant defense mechanisms in the CNS diverge substantially from those in peripheral tissues such as erythrocytes, where the glutathioneNADPH system is well characterized and robust

In the untranslated regions (UTRs) of genes encoding a variety of iron regulatory molecules (including DMT1 and TFR1), the IRP1 and IRP2 bind to the iron response elements (IREs)

Moreover, hydrogen can suppress cellular pyroptosis by reducing the expression of the inflammatory vesicle NLR family pyrin domain-containing protein 3 (NLRP3), which positively influences the prevention and treatment of neuropathic pain [55]

Allergy 78(7):18471865