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Pathophysiology and Treatment of COPD Oxidative stress is an important driving mechanism of COPD via the initiation of chronic inflammation associated with stimulated mucus secretion, induction of cell senescence and damaged autophagy, decreased DNA repair, enhanced autoimmunity, and impaired response to corticosteroid treatment [104]

Piya Ghose, Alina Rashid, Peter Insley, Meera Trivedi, Pavak Shah, Anupriya Singhal, Yun Lu, Zhirong Bao, Shai Shaham, "EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans", Nature cell biology 20 (4): (2018)

Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS, Nikiforov MA

Int J Mol Sci 23(14)

doi:10.1210/jcem.86.1.7103 6
