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van Vliet S, Provenza FD, Kronberg SL

After bolus intravenous administration of Lcarnitine in doses ranging from 20 to 100 mg/kg, the volume of distribution is 0.20.3 L/kg, and the fraction excreted unchanged in urine is 0.730.95, suggesting that renal clearance of Lcarnitine is dose dependent due to saturable renal reabsorption at supraphysiological concentrations

Six RCTs [17, 18, 3235] involving 417 patients provided moderate certainty evidence (Table 2) that L-carnitine supplementation has no difference in changes in the BMI (MD: 0.00, 95%CI: 0.23 to 0.24)

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