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Description
The astroglial activation was further confirmed by the depicted enhancement in GFAP immunoexpression in MSG-intoxicated group
Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)

Both doses of the drugs were well tolerated

Future research needs to further optimize the biocompatibility and targeting of nanomaterials and explore their safety and efficacy in clinical applications

At the same time, randomized clinical trials are needed to precisely determine the optimal timing of dietary intervention and standardize the dietary protocol for macronutrient ratios and calorie intake
