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reported that one-time 1020 ppm iNO administration to moderate to severe COVID-19 ARDS patients with pneumonia failed to improve oxygenation [246], as did two separate studies using a single 2030 ppm dose of iNO in mechanically ventilated ICU patients with COVID-19 refractory hypoxemia [247,248]

First, whether doses larger than 2.88 mg/kg would further improve MWM performance is worth exploring in future studies

Due to its electrophilic nature, 4-HNE interacts with cysteine, histidine, and lysine residues in proteins, forming Schiff bases and Michael adducts that exhibit pro-oxidant, pro-inflammatory, and pro-apoptotic properties

TABLE 2 Treatment strategy of ferroptosis in cardio-cerebrovascular diseases

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