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Ketone administration for seizure disorders: history and rationale for ketone esters and metabolic alternatives

Abstract Members of the protein kinase D (PKD) family (PKD1, 2, and 3) integrate hormonal and nutritional inputs to regulate complex cellular metabolism

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Furthermore, NO increases blood flow by relaxing the smooth vascular muscle and abdominal, and central obesity leads to an imbalanced production of fat-derived metabolic products, hormones, and adipokines that predispose to a state endothelial dysfunction, activating NADPH oxidase [67]