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Description
The antiproliferative effect of calcitriol involves multiple pathways, such as the expression of cyclin-dependent kinase inhibitors (i.e., CDKN1A and CDKN1B), the production of growth factors (i.e., TGF-, IGF) and miRNAs, the regulation of cancer stem cell proliferation, tumor angiogenesis, epithelial-mesenchymal transition, and the activation of caspases (49, 5356)

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For testing the reactivity of compound T13 with GST, T13 (10 M) was reacted with or without GSH (1 mM) and GSTP1 (10 g/mL) at 37C for 1 h, and the product was analyzed by monitoring MRM chromatograms for T13 and T13-GSH

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No single recommendation is appropriate for every patient
