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Liver Disease: Individuals with liver disease may have impaired vitamin B12 metabolism, and injections may need to be closely monitored

For metabolism of NR, NRK1 is expressed in most tissues but is absent in the spleen and white adipose tissue, while NRK2 is only present in skeletal muscle, heart, and white adipose tissue (WAT) 40

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Moreover, CD38 deficiency-mediated inhibition of the biogenesis, secretion, and internalization of SA-sEVs by senescent VSMCs was partially involved in reestablishing the function of the mitochondrial-lysosomal axis in smooth muscle cells

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