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[,] Role of Sodium-Glucose Co-Transporter 2 Inhibitors (SGLT2) Inhibitors SGLT2 inhibitors work in heart failure by blocking the SGLT2 protein in the proximal tubule of the nephron, reducing the reabsorbed glucose and sodium in the blood
Enhanced collagen synthesis supports connective tissues like tendons and ligaments
In vitro studies using peripheral blood mononuclear cells from healthy controls and SS patients have shown that the combined use of leflunomide (LEF) and hydroxychloroquine (HCQ) can dose-dependently inhibit the proliferation of T and B cells, and reduce levels of key pro-inflammatory cytokines (CXCL13, IFN-, IFN-) and immunoglobulins (IgG, IgM) associated with SS pathology
The validation was based on controlled clinical studies in a Japanese patient population (Chihara et al
[DOI] [PMC free article] [PubMed] [Google Scholar] 237.Yuan Q., Yang W., Zhang S., Li T., Zuo M., Zhou X., Li J., Li M., Xia X., Chen M., et al
