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The CNS GLP- 1 receptors are not necessary for the physiological regulation of blood glucose levels by endogenous GLP- 1 or the pharmacological control of glucose homeostasis that depends on GLP- 1 receptors, although further research is needed to investigate the possible role of GLP- 1 receptors expressed outside the beta cell, including within the enteric and peripheral nervous systems, in improving beta cell function through enteral glucose mediation [70, 84]

Other groups have reported novel LNP designs that enable intratumoral delivery of bacterial enzyme mRNAs or redirect T cell immunity toward tumors, both resulting in significant tumor inhibition in preclinical models [293, 294]

Cell-cell junctions organize structural and signaling networks

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