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Users at lower body fat levels have less adipose tissue available for lipolysis, and the marginal returns from fat-mobilizing agents diminish as body fat decreases

Food intolerances, particularly to lactose or fructose, may become more apparent during dietary transitions

Besides its effects on the LH, in rats, tesofensine did not produce head weaving stereotypy at therapeutic doses, suggesting that it may be a safer and more tolerable option to treat obesity than other appetite suppressants such as phentermine

doi:doi:10.1161/CIRCULATIONAHA.117.029901 Ohara T, Farhoudi M, Bang OY, Koga M, Demchuk AM