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If left untreated, the deficiency can cause severe neurologic problems and blood diseases

In this guide, the term nootropics is used in the broader modern sense, which includes many brain supplements, not only the strict original definition of true nootropics

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That is, the main function attributed to the tight junction proteins is the gate and fence function, which allows the paracellular transport of some solutes and molecules but prevents the intramembrane transport of proteins, lipids, and microbial-derived peptides 25,26

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