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With glucose metabolizing into pyruvate, it enters the mitochondria and participates in the tricarboxylic acid cycle (TCA), where reduced nicotinamide adenine dinucleotide (NADH) and reduced flavin adenine dinucleotide (FADH 2 ) are produced and then go through the respiratory chain pushing the adenosine triphosphate (ATP) pump to produce large amounts of ATP

The supplements are widely available and can be found in various forms, including capsules, tablets, and liquid formulations

Recent studies have reported promising findings about the potential therapeutic effects of ALA in NDs, which are summarized in Table 1

The dysregulation of Ca2+ signaling can cause protein misfolding and secretion (64)