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This can ultimately contribute to the destabilization of mitochondrial complexes I and III due to the combined effects of oxidative stress, genetic mutations, altered lipid composition, decreased coenzyme Q10 levels, and impaired mitochondrial dynamics

Pekkarinen et al

Effect of Calcitriol in Inhibiting the Cancer Cell Growth and Promoting Apoptosis in ErbB2-positive Breast Cancer Cells

Similarly, several novel MCT1/4 inhibitors are under investigation, including AZD3965, which has demonstrated anti-tumor effects by inhibiting MCT1, disrupting lactate metabolism in tumors, and causing lactate accumulation within cancer cells

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