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Dietary Supplements for Exercise and Athletic Performance Health Professional Fact Sheet [Internet]

Itaconate has anti-inflammatory properties through activation of nuclear factor erythroid 2-related factor 2 (Nrf2) via Kelch-like ECH-associated protein 1 (KEAP1) alkylation [97]

This insufficient targeting leads to low NADs concentrations at the disease site and unintended gene silencing or activation, potentially causing safety issues by requiring higher doses
The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP

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