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The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

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Dermal fillers are nonsurgical injectable treatments made from hyaluronic acid (like Juvderm, Restylane) and other advanced formulas that add volume, smooth lines, and improve facial contours

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Pregnant or breastfeeding women should not use MOTS-c

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L-proline, L-glycine: Support connective tissue and collagen

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10.1016/j.ijsu.2016.02.045 31 ChenH

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