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Furthermore, ROS can be released in response to a variety of stimuli, such as TNF- and lipopolysaccharide [3646, 169] and they serve as intracellular signals for the activation of redox-sensitive transcription factors [2, 3, 1618, 26, 27, 3646, 164170]

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In general, many of the anticancer effects of curcumin are related to the simultaneous modulation of several epigenetic mechanisms, with studies suggesting the negative regulation or inhibition of DNMTs and HDACs jointly by this polyphenol (Shu et al., 2011)