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Approximately 90 to 95% of a dose of paracetamol is metabolized in liver into non-toxic products, which are excreted in the urine after conjugation with glucuronic or sulphuric acid, while about 3% is excreted unchanged

Feist Cardiovascular Research Fellowship to RP and the Endowed Chair in Diabetes to SKJ from the Center for Cardiovascular Diseases and Sciences (CCDS), LSUHSC, Shreveport, as well as grants to SKJ from the National Institutes of Health/National Center for Complementary and Integrative Health (RO1 AT007442, 2013-16)

In one mechanism, APAP becomes hepatotoxic after its metabolism by CYP2E1 and other P450 isoforms, and produces a reactive metabolite named N -acetyl- p -benzoquinone imine (NAPQI) [110, 271, 272]

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Kaeser PS, Regehr WG (2017): The readily releasable pool of synaptic vesicles