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Excessive consumption may cause laxative effects due to polyols

L., Selvarajah, D., Emery, C

Bolland, S

Although such a modulation of the action potential might be deemed to have minimal effects on the contractile function of cardiac cells, it is evident that TMAO is transiently limiting the amplitude of contraction as the washout of TMAO reverses the dampening of contractions (Figure 8)

In contrast, VPA-response has been observed in SMA patient cell lines (16,17), one-third of SMA subjects (18) and in spinal cord of type III-like SMA mice (24)
