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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Medina MA, Quesada AR, Nez de Castro I

88 found that the activated PPAR could induce the expression of its target gene uncoupling protein 2 (UCP2) and increase the activity of fatty acid -oxidation-related enzymes and peroxidase in mitochondria

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Subsequently, the aspartateglutamate antiporter (encoded by SLC25A13 gene) exports aspartate into the cytosol where cytosolic glutamic-oxaloacetic transaminase (GOT1) transfers an amino group from aspartate to ketoglutarate to produce glutamate and oxaloacetate to complete the cycle, which is, in turn, reduced to malate in conjunction with oxidizing NADH to NAD + by cytosolic MDH (Fig