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The end-products of lipid peroxidation (HNE and MDA) cause protein damage by addition reactions with lysine amino groups, cysteine sulfhydryl groups, and histidine imidazole groups (Esterbauer et al., 1991

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Cholesterol homeostasis is controlled by two NCR proteins: NCR-1 absorbs cholesterol and promotes synapse development, whereas NCR-2 uses cholesterol and hinders synapse development