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However, disruption of other mitochondrial enzymes/complexes of cerebral energy metabolism (e.g., -ketoglutarate dehydrogenase complex (KGDHC) and pyruvate dehydrogenase complex (PDHC)) may also contribute to decreased energy production in neurodegenerative disease (reviewed by Gibson et al., 2005, Kiss et al., 2013)

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The likelihood of parent-to-child transmission can be reduced by vaccination (Lee 2006) (see below)

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The fact that one of the CSDs is lost in the NTR of ERO1B found in secretory tissues of land animals, suggests its loss is associated with increased activity of ERO1B