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This Review highlights emerging mechanisms of acquired resistance to agents targeting the androgen receptor in castration-resistant prostate cancer, which fall into the three broad categories of restored androgen receptor (AR) signalling, AR bypass signalling and complete AR independence.

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Though some studies have tested doses as large as 4.5 grams, most studies agree that the effective dose is 1-2 grams per day

It is also used as an antidote to paracetamol (acetaminophen) poisoning and found to be effective for the prevention of car-diotoxicity by doxorubicin and hae norrhagic cystitis from oxazaphosphorines.After an oral dose of N-acetylcysteine 200 to 400mg the peak plasma concentration of 0.35 to 4 mg/L is achieved within 1 to 2 hours