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The intracellular metabolism of glutamate in -cells involves mitochondrial glutamate dehydrogenase, glutamate decarboxylase (GAD), glutamine synthetase, and the synthesis of glutathione (140)

In contrast, prolonging the stressful episode by rendering it chronic leads to exaggerated spine elimination that largely exceeds spine formation and thus results in strongly reduced net spine density (Liston and Gan, 2011)

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