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22.0% in the placebo group) in the primary composite endpoint of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularization, or unstable angina in patients with established ASCVD or with diabetes and other risk factors [65]

Older adults (over 60) losing weight on GLP-1 medications face higher risks from muscle loss because age-related sarcopenia is already reducing their lean mass

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However, TMAO improved risk stratification for death/MI at 6 months by down-classifying the risk of some patients (Suzuki et al., 2017)

The Norwegian Medicines Agency has issued warnings in 2007 and 2009 about the use of "Melanotan" sold online, while a spokesman for the Australian Therapeutic Goods Administration warned consumers to be "very wary" of using it