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We further examined the sufficiency of C22 ceramide in this effect, and the results showed that dietary C22 ceramide induced the expression of gst-4p ::GFP and SKN-1 targets, enhanced stress resistance, and extended lifespan in germline-intact wild-type animals (Supplementary Fig

6 Interestingly, the human gut microbiota also produce BCFAs, and the production is influenced by food intake and diet-mediated changes in the gut microbiome

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