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Free radicals, toxins, and oxidants can damage cellular structures, leaving cells without the ability to perform their functions adequately

Iron overload has been shown to impair mitochondrial biogenesis and dynamics, leading to altered mitochondrial morphology and function

doi: 10.1215/15228517-2008-095 231 BernardiRJLoweryARThompsonPABlaneySMWestJL

So CagriSema applies two independent signals that both converge on decelerating the stomach: cagrilintide via amylin/AMY receptors in the area postrema and its vagal output, and semaglutide via GLP-1 receptors on vagal afferents and in the brainstem

Cell Physiol 40(7):683690