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We hypothesize that SUMOylation of TDP-43 is an early event regulating TDP-43 proteostasis, however if overwhelmed other systems such as phosphorylation or protein cleavage may help respond to regulate TDP-43

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AP: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writingoriginal draft, Writingreview and editing

Therefore, new scoring methods that take into account MET staining in the cytoplasm, in addition to the plasma membrane, will enhance patient selection and subsequent outcomes

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