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Description
This investigational therapy is being given as an intravenous (into a vein) infusion
Mitochondrial dysfunction in HD includes impaired electron transport chain activity, reduced mitochondrial biogenesis, and defective mitophagy, all of which contribute to increased oxidative stress and neuronal damage [165]
The pathogenesis is not fully understood yet
This leads to increased levels of cAMP, which in turn activates PKA
When Vitamin E neutralizes a free radical in a cell membrane, it becomes oxidized
