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Nephrotic syndrome: A review

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Furthermore, DEHP may increase TSHR expression with the subsequent activation of downstream effectors of the phosphatidylinositol-3 kinase (PI3K)/AKT and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathways, which regulate cell growth, differentiation, and apoptosis and whose genetic alterations have been associated with the onset and progression of TC [144,145,146]

However, it should be noted that growth retardation caused by selenium deficiency may also be associated with the deregulation of bone metabolism 65

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