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The inhibition of DNMT1 with 5-aza-2-deoxycytidine has been observed to decrease the amount of 5 mC in mitochondria associated to the improvement of mt-COX2 expression (87)

& Jessberger, S
doi: 10.1371/journal.pone.0231136 [DOI] [PMC free article] [PubMed] [Google Scholar] 389

You wouldn't expect to maintain fitness indefinitely from three months of working out followed by permanent couch time
Am J Physiol Heart Circ Physiol 2007;292:H76H82
